Levonordefrin is 1/6 as potent as epinephrine.

Levonordefrin is 1/6 as potent as epinephrine.

• A. True
• B. False
• C. Not sure
• D. Not applicable

Answer: (A)

Levonordefrin and epinephrine are both vasoconstrictors used with local anesthetics, with epinephrine serving as the reference standard for potency. When you compare their effects directly, levonordefrin is about one-sixth as potent as epinephrine. So, for a similar vasoconstrictive effect, you would need roughly six times more levonordefrin by weight. This difference in potency is reflected in their typical concentrations used in dental anesthetics (levonordefrin often at around 1:20,000 versus epinephrine at 1:100,000 or 1:200,000). Therefore, the statement is true. Saying otherwise would go against established pharmacologic data; uncertainty or inapplicability doesn’t apply here.

Levonordefrin and epinephrine are both vasoconstrictors used with local anesthetics, with epinephrine serving as the reference standard for potency. When you compare their effects directly, levonordefrin is about one-sixth as potent as epinephrine. So, for a similar vasoconstrictive effect, you would need roughly six times more levonordefrin by weight. This difference in potency is reflected in their typical concentrations used in dental anesthetics (levonordefrin often at around 1:20,000 versus epinephrine at 1:100,000 or 1:200,000). Therefore, the statement is true. Saying otherwise would go against established pharmacologic data; uncertainty or inapplicability doesn’t apply here.